Fig. 1.
Neuropeptide precursors and their predicted neuropeptides in Platynereis. Schematic drawings of Platynereis neuropeptide precursors are shown with the location of the signal peptide (blue), the amidated (yellow) and nonamidated (green) neuropeptides, and cleavage sites (red). Sequences and the number of neuropeptides predicted from each precursor are shown. Sequence logos were generated on the basis of alignments of all neuropeptides from one precursor. The amidation signature C-terminal Gly is included in the logos. For the L11 precursor no logo is shown because the peptides are not similar. Neuropeptides used for the pharmacological experiments and immunizations (with an extra N-terminal Cys) are shown in red. For SPY and WLD we did not obtain a working antibody.